DECIDE


A Patient-Centered Comparative Effectiveness Study of Metformin and Insulin for the Treatment of Gestational Diabetes



Because the best treatment shouldn't be a guess!

About DECIDE Trial

Gestational diabetes mellitus (GDM) is a common issue during pregnancy that can lead to health complications for both the mother and baby. Keeping blood sugar at ideal levels is crucial to reduce the risk of problems. About one in four women with GDM need medication to manage their blood sugar levels. Typically, insulin injections have been the go-to treatment, but lately, oral metformin has become more popular as an alternative. Both insulin and metformin help lower the risk of complications during pregnancy, but there's not enough data comparing how effective they are in a diverse U.S. population.

DECIDE is a large research study led by the Ohio State University Wexner Medical Center and involving 20 clinical sites across the U.S. Pregnant women with GDM can join the study if they meet certain criteria, and will be assigned to initially receive either metformin or insulin and followed up for two years after giving birth. Some women may require treatment with both metformin and insulin. The study will carefully assess important outcomes, including pregnancy complications, child health, and patient-reported experiences.

  • Compare the effectiveness of metformin and insulin in treating women with gestational diabetes mellitus (GDM) in a diverse population.
  • Explore the experiences of GDM treatment with metformin and insulin.
  • Evaluate how metformin and insulin for glucose control during pregnancy impact the pregnancy experience for women with GDM.

About PCORI

DECIDE is funded by the Patient-Centered Outcomes Research Institute (PCORI), a nonprofit group that funds research to help patients and others understand their health and treatment options better. PCORI focuses on comparative clinical effectiveness research (CER), which looks at different medical treatments to help people make informed choices.

PCORI values putting patients first in research and makes sure patients and healthcare experts work together from start to finish, deciding on research topics, designing studies, and sharing results.