About DECIDE Trial
Gestational diabetes mellitus (GDM) is a common issue during pregnancy that can lead to health complications for both the mother and baby. Keeping blood sugar at ideal levels is crucial to reduce the risk of problems. About one in four women with GDM need medication to manage their blood sugar levels. Typically, insulin injections have been the go-to treatment, but lately, oral metformin has become more popular as an alternative. Both insulin and metformin help lower the risk of complications during pregnancy, but there's not enough data comparing how effective they are in a diverse U.S. population.
DECIDE is a large research study led by the Ohio State University Wexner Medical Center and involving 20 clinical sites across the U.S. Pregnant women with GDM will be randomly assigned to receive either metformin or insulin and followed up for two years after giving birth. The study will assess various outcomes, including pregnancy complications, child health, and patient-reported experiences.
- Compare the effectiveness of metformin and insulin in treating women with gestational diabetes mellitus (GDM) in a diverse population.
- Investigate the reasons why women with GDM choose metformin or insulin as their treatment option.
- Evaluate how the choice between metformin and insulin impacts the pregnancy experience for women with GDM.
Research Sites
About PCORI
DECIDE is funded by the Patient-Centered Outcomes Research Institute (PCORI), a nonprofit group that funds research to help patients and others understand their health and treatment options better. PCORI focuses on comparative clinical effectiveness research (CER), which looks at different medical treatments to help people make informed choices.
PCORI values putting patients first in research and makes sure patients and healthcare experts work together from start to finish, deciding on research topics, designing studies, and sharing results.